Focusing on IL-6/STAT3 Pathway shows the approach of anti-IL-6 antibody (tocilizumab) in the treatment of multiple hydrocephalus

Abstract

Background: Most hydrocephalus are characterized by a high prevalence of condyloma acuminatum, which results in a
large number of cystic cavities in the ventricles. Surgery is performed through a neuroendoscope, and a window is
opened in the middle of the hole to reduce the number of shunts used. However, muscle mass continues to increase,
leading to the need for multiple operations and an increase in disease and mortality.
Purpose: To conduct a literature review before starting preclinical and clinical research on the underlying
pathophysiological and biochemical changes associated with multi-chamber hydrocephalus, with the aim of targeting
the disease with pharmacological agents that can inhibit these changes.
Method: Perform literature search through PubMed. The following parts were searched: multiple hydrocephalus,
hydrocephalus and other diseases with multiple causes and well-known biochemical changes, as well as pharmacologypathology.
Results: Hydrocephalus chronic ventriculitis carried a large number of people, leading to the proliferation of
subependymal glial cells and the appearance of glial cells in the ventricle, creating multiple compartments. In other
diseases caused by treatment and high-grade IL-6 breast cancer, the production of IL-6/STAT3 proves the pathway
leading to the inhibition of cell proliferation and apoptosis. The US Food and Drug Administration (FDA) has approved
the use of Tocilizumab antibody for IL-6 receptor antibody (IL-6R antibody) in autoimmune diseases. In addition,
medical testing for the use of Tocilizumab in certain CNS issues is ongoing.
Conclusion: The spread of the septum causes hydrocephalus in many chambers that can be caused by chronic
inflammation and the formation of the IL-6 / STAT3 pathway. Therefore, tocilizumab is an IL-6R antibody that can
prevent the spread of genitalia. Further research is needed to determine if tocilizumab prevents chronic ventriculitis and
multiple chamber hydrocephalus and cell proliferation.